Compounding is about addressing issues that may not be obvious on the surface in order to correct the root of the problem!

There are times when real health problems are not adequately addressed with prescription medication currently on the market.  Wilson’s Temperature Syndrome (WTS) is a great example of the tremendous benefit that compounding pharmacy can deliver. 

WTS is on the order of 10 times more common that Hashimoto’s Thyroiditis. WTS causes classic symptoms of slow metabolism and low body temperature seen in hypothyroidism such as fatigue, depression, easy weight gain, PMS, panic attacks, fibromyalgia, dry skin, hair loss, and dozens of others.  Yet, in WTS the oral body temperature averages less than 98.6 even though the thyroid stimulating hormone (TSH) level is normal (TSH is high in hypothyroidism).  The good news is that WTS is often completely reversible with proper treatment (often within a matter of months) such that the temperature and symptoms remain improved even after the treatment has been discontinued (unlike hypothyroidism which is often thought of as a life-long diagnosis).

watson-chart

A recent study in Italy showed that the overnight temperature patterns are identical between hypometabolic and normometabolic people.  Low body temperatures become apparent during waking hours.  That goes along with why Dr. Wilson does not recommend morning axillary temperatures, but daytime temperatures as a guide (take the temperature 3 times a day, 3 hours apart, starting 3 hours after waking and take the average).  

[http://www.wilsonssyndrome.com/identify/how-are-body-temperatures-measured/]

Chronobiol Int. 2015 Mar;32(2):299-302. doi: 10.3109/07420528.2014.983603. Epub 2014 Nov 21.

Evidence of a diurnal thermogenic handicap in obesity.

Grimaldi D1, Provini FPierangeli GMazzella NZamboni GMarchesini GCortelli P.

Research has shown that the body temperature closely correlates with metabolic rate.  Many doctors are finding that body temperature correlates with low thyroid symptoms far better than thyroid blood tests do.  It’s easy to see why this would be since most of the active form of thyroid hormone (T3) is produced inside the cells throughout the body, not in the thyroid gland. Blood tests aren’t a good indicator of metabolic rate because they don’t measure what’s happening inside the cells of the body, or the resulting body temperature.

Body temperature and metabolic rate (O2 consumed/min) were tracked in a mouse over a 24-hour period.  The one to one correlation between the two shows that body temperature is an exact measure of metabolic rate, to a degree that is unimaginable for any thyroid blood tests).

The intracellular deiodination of T4 to T3 is regulated by the body.  This conversion of T4 to T3 can be impaired by stress, toxins, and other imbalances.  T3 therapy can bypass this impairment while decreasing TSH, T4, and RT3.  T4 and RT3 strongly down-regulate T4 to T3 conversion. So, lowering these for a time may help up-regulate T4 to T3 conversion which may be part of how T3 therapy often leads to such dramatic and persistent improvement in patients with WTS. 

T3 therapy consists of taking one capsule every 12 hours of pure T3 powder mixed with a sustained release agent. The dose is increased each day until the course reaches its peak and/or the symptoms resolve. The treatment is then tapered off by decreasing the dose every 2 or 3 days. Another cycle of T3 therapy can be administered if the symptoms have not completely resolved, and a higher maximum dose can be considered.

Website

Dr. Wilson’s website is a trove of information regarding Wilson’s Temperature Syndrome, its indicators, the therapy, the medication and much more. On Dr. Wilson’s website http://www.wilsonssyndrome.com both patients and doctors alike can find educational material on symptoms and therapeutic protocols (especially, see the video tab that describes the Simplified Protocol and a printable instruction sheet).

Products

Tailor Made Compounding offers a variety of T3 starter packs that fall under two distinct dosing protocols, the simplified protocol, and the original protocol. Dr. Wilson and Tailor Made Compounding recommend that doctors begin patients on the simplified protocol and switch to the original protocol if necessary. Below you will find the information for and variations of both types of protocols.

Simplified Protocol

Starter Pack 1 – $48.00

7.5 mcg

6 capsules

15 mcg

6 capsules

22.5 mcg

6 capsules

30 mcg

6 capsules

37.5 mcg

6 capsules

45 mcg

6 capsules

52.5 mcg

6 capsules

60 mcg

6 capsules

67.5 mcg

6 capsules

75 mcg

6 capsules

 

Starter Pack 2 – $64.00

7.5 mcg

8 capsules

15 mcg

8 capsules

22.5 mcg

8 capsules

30 mcg

8 capsules

37.5 mcg

8 capsules

45 mcg

8 capsules

52.5 mcg

8 capsules

60 mcg

8 capsules

67.5 mcg

8 capsules

75 mcg

8 capsules

 

Starter Pack 3 – $57.60

7.5 mcg

6 capsules

15 mcg

6 capsules

22.5 mcg

6 capsules

30 mcg

6 capsules

37.5 mcg

6 capsules

45 mcg

6 capsules

52.5 mcg

6 capsules

60 mcg

6 capsules

67.5 mcg

6 capsules

75 mcg

6 capsules

82 mcg

6 capsules

90 mcg

6 capsules

 

Starter Pack 4 – $76.80

7.5 mcg

8 capsules

15 mcg

8 capsules

22.5 mcg

8 capsules

30 mcg

8 capsules

37.5 mcg

8 capsules

45 mcg

8 capsules

52.5 mcg

8 capsules

60 mcg

8 capsules

67.5 mcg

8 capsules

75 mcg

8 capsules

82 mcg

8 capsules

90 mcg

8 capsules

 

The dosing instructions for the simplified protocol are to simply take two capsules each day exactly 12 hours apart and increase in strength by 7.5 mcg each day. Once the patient has peaked they will maintain that dose for a few days before starting to wean themselves off the medication as they decrease the dose by 7.5 mcg every two days. This can be diagrammed as such:

Day 1: 7.5 BID

Day 2: 15 BID

Day 3: 22.5 BID

Day 4: 30 BID

Day 5: 37.5 BID

Day 6: 45 BID

Day 7: 52.5 BID

Day 8: 60 BID

Day 9: 67.5 BID

Day 10: 75 BID

Day 11: 75 BID

Day 12: 75 BID

Day 13: 67.5 BID

Day 14: 67.5 BID

Day 15: 60 BID

Day 16: 60 BID

Day 17: 52.5 BID

Day 18: 52.5 BID

Day 19: 45 BID

Day 20: 45 BID

Day 21: 37.5 BID

Day 22: 37.5 BID

Day 23: 30 BID

Day 24: 30 BID

Day 25: 22.5 BID

Day 26: 22.5 BID

Day 27: 15 BID

Day 28: 15 BID

Day 29: 7.5 BID

Day 30: 7.5 BID

 

Original Protocol

Starter Pack 1 – $53.00

7.5 mcg

30 capsules

15 mcg

30 capsules

22.5 mcg

12 capsules

30 mcg

12 capsules

37.5

12 capsules

 

Starter Pack 2 – $74.00

7.5 mcg

16 capsules

15 mcg

16 capsules

22.5 mcg

8 capsules

30 mcg

8 capsules

37.5 mcg

50 capsules

 

Starter Pack 3 – $144.00

7.5 mcg

30 capsules

15 mcg

30 capsules

22.5 mcg

12 capsules

30 mcg

12 capsules

37.5 mcg

12 capsules

45 mcg

12 capsules

52.5 mcg

12 capsules

60 mcg

12 capsules

67.5 mcg

12 capsules

75 mcg

12 capsules

82.5 mcg

12 capsules

90 mcg

12 capsules

 

The original protocol follows the same basic directions as the simplified protocol. The patient still does the medication twice daily exactly 12 hours apart from each other, but the dose doesn’t increase by the steady 7.5 mcg like it does in the simplified protocol and instead is determined by the doctor prescribing the T3. The starter packs are made up of different amounts of different strength capsules so that the capsules can be combined to reach higher numbers. It is more of a DIY approach than the simplified protocol where the capsules come in the designated strength to be dosed.

 

 

 

We at Tailor Made are proud of our ability to find the problem and effectively treat people with our customized medications. Let us help you today!

Denis Wilson, MD

Originator of Sustained Release T3

Identified Wilson’s Temperature Syndrome

Recommends Tailor Made Compounding for T3

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